Document Detail


Stabilization of Tc-99m D,L-HMPAO preparations as a leucocyte labelling agent.
MedLine Citation:
PMID:  9745694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An attempt was made to use stabilized Tc-99m D,L-HMPAO (S-HMPAO) to label leucocytes. The radiochemical purity of Tc-99m D,L-HMPAO, labelling efficiency of leucocytes, cell viability of labelled leucocytes, and stability of S-HMPAO labelled leucocytes were calculated. In comparison with commercial Tc-99m D,L-HMPAO (C-HMPAO) without stabilization, immediately, at 0.5, 1, 2, 4, and 6 h after HMPAO preparation, the radiochemical purity of S-HMPAO and the labelling efficiencies of S-HMPAO labelled leucocytes were higher. S-HMPAO is more stable than C-HMPAO and can provide higher leucocyte labelling efficiency. S-HMPAO, therefore, has the potential to replace C-HMPAO as a leucocyte-labelling agent.
Authors:
C H Kao; W T Huang; C S Tsai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  49     ISSN:  0969-8043     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-10-15     Completed Date:  1998-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1595-8     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Cell Survival
Drug Stability
Humans
Kinetics
Leukocytes / cytology,  metabolism*
Technetium Tc 99m Exametazime / blood*,  chemistry*
Chemical
Reg. No./Substance:
100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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