| Stabilization of Gas Bubbles Released from Water-Soluble Carbohydrates Using Amphiphilic Compounds: Preparation of Formulations and Acoustic Monitoring of Bubble Lifetime. | |
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MedLine Citation:
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PMID: 21957396 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The ultrasound contrast agents Echovist(®) and Levovist(®) (Bayer AG, Schering AG, Germany) are based on the release of gas bubbles from milled α-d-galactose. In diagnostic ultrasound, for this class of contrast agents, there is a need for prolonged contrast duration. To investigate if new carbohydrate compositions could prolong the lifetime of the gas bubbles, α-d-galactose was mixed with other carbohydrates or amphiphiles with varying log P. Acoustic attenuation vs. time (390 s) area under the curve (A(390)) and bubble half-time (t½) were used as measures of prolonged lifetime of gas bubbles. The products, to which 0.1% of a lipophilic carboxylic acid (5β-cholanic acid, behenic acid, and melissic acid) has been added, showed more than 5, 7 and 11 times enhancement of A(390), respectively, compared with the reference compound 2 (RC2) corresponding to the commercial product Levovist®. The half-time t ½ of the same compounds was prolonged more than 6 times compared with RC2. A partial least square (PLS) statistical analysis confirmed that, for additives, high log P carboxylic acids lead to the highest A(390). The present results bear a promise of products with a more persistent in vivo ultrasound contrast effect than the commercially available agents. |
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Authors:
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Lars Hoff; Per A Foss; Knut Dyrstad; Jo Klaveness; Pål Rongved |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-13 |
Journal Detail:
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Title: Journal of surfactants and detergents Volume: 14 ISSN: 1558-9293 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-9-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101527053 Medline TA: J Surfactants Deterg Country: - |
Other Details:
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Languages: ENG Pagination: 585-593 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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