Document Detail


Stabilization of Gas Bubbles Released from Water-Soluble Carbohydrates Using Amphiphilic Compounds: Preparation of Formulations and Acoustic Monitoring of Bubble Lifetime.
MedLine Citation:
PMID:  21957396     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The ultrasound contrast agents Echovist(®) and Levovist(®) (Bayer AG, Schering AG, Germany) are based on the release of gas bubbles from milled α-d-galactose. In diagnostic ultrasound, for this class of contrast agents, there is a need for prolonged contrast duration. To investigate if new carbohydrate compositions could prolong the lifetime of the gas bubbles, α-d-galactose was mixed with other carbohydrates or amphiphiles with varying log P. Acoustic attenuation vs. time (390 s) area under the curve (A(390)) and bubble half-time (t½) were used as measures of prolonged lifetime of gas bubbles. The products, to which 0.1% of a lipophilic carboxylic acid (5β-cholanic acid, behenic acid, and melissic acid) has been added, showed more than 5, 7 and 11 times enhancement of A(390), respectively, compared with the reference compound 2 (RC2) corresponding to the commercial product Levovist®. The half-time t ½ of the same compounds was prolonged more than 6 times compared with RC2. A partial least square (PLS) statistical analysis confirmed that, for additives, high log P carboxylic acids lead to the highest A(390). The present results bear a promise of products with a more persistent in vivo ultrasound contrast effect than the commercially available agents.
Authors:
Lars Hoff; Per A Foss; Knut Dyrstad; Jo Klaveness; Pål Rongved
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-13
Journal Detail:
Title:  Journal of surfactants and detergents     Volume:  14     ISSN:  1558-9293     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-9-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101527053     Medline TA:  J Surfactants Deterg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  585-593     Citation Subset:  -    
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