| Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. | |
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MedLine Citation:
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PMID: 19099546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The stability of ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate in topical formulations was investigated by direct reverse phase high performance liquid chromatography after sample dilution with a suitable buffer - organic solvent mixture. Ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate are derivatives of ascorbic acid which differ in hydrolipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. According to the results, ascorbyl esters showed significant differences: sodium ascorbyl phosphate and magnesium ascorbyl phosphate are more stable derivatives of vitamin C than ascorbyl palmitate and may be easily used in cosmetic products. |
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Authors:
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A I Segall; M A Moyano |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cosmetic science Volume: 30 ISSN: 1468-2494 ISO Abbreviation: Int J Cosmet Sci Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007161 Medline TA: Int J Cosmet Sci Country: England |
Other Details:
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Languages: eng Pagination: 453-8 Citation Subset: IM |
Affiliation:
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Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina. asegall@ffyb.uba.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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chemistry Ascorbic Acid / analogs & derivatives*, chemistry Chromatography, High Pressure Liquid Cosmetics / chemistry Drug Stability Emulsions / chemistry Kinetics Thioctic Acid / chemistry* Vitamin A / chemistry* Vitamin E / chemistry* Vitamins / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Cosmetics; 0/Emulsions; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 62-46-4/Thioctic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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