Document Detail

Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E.
MedLine Citation:
PMID:  19099546     Owner:  NLM     Status:  MEDLINE    
The stability of ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate in topical formulations was investigated by direct reverse phase high performance liquid chromatography after sample dilution with a suitable buffer - organic solvent mixture. Ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate are derivatives of ascorbic acid which differ in hydrolipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. According to the results, ascorbyl esters showed significant differences: sodium ascorbyl phosphate and magnesium ascorbyl phosphate are more stable derivatives of vitamin C than ascorbyl palmitate and may be easily used in cosmetic products.
A I Segall; M A Moyano
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cosmetic science     Volume:  30     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-8     Citation Subset:  IM    
Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina.
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MeSH Terms
Antioxidants / chemistry
Ascorbic Acid / analogs & derivatives*,  chemistry
Chromatography, High Pressure Liquid
Cosmetics / chemistry
Drug Stability
Emulsions / chemistry
Thioctic Acid / chemistry*
Vitamin A / chemistry*
Vitamin E / chemistry*
Vitamins / chemistry*
Reg. No./Substance:
0/Antioxidants; 0/Cosmetics; 0/Emulsions; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 62-46-4/Thioctic Acid

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