| Stability of substantia nigra pars reticulata neuronal discharge rates during dopamine receptor blockade and its possible mechanisms. | |
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MedLine Citation:
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PMID: 16791106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is hypothesized that substantia nigra pars reticulata neurons become overactive during a deficit of dopamine transmission. In this study, we examined how acute dopamine receptor blockade (SCH23390 and eticlopride) affects impulse activity of substantia nigra pars reticulata neurons and their response to iontophoretic gamma-amino-n-butyric acid in awake, unrestrained rats. No changes in discharge rate were found during complete dopamine receptor blockade, but these neurons showed a diminished response to gamma-amino-n-butyric acid, suggesting gamma-amino-n-butyric acid receptor hyposensitivity. This may result from tonic increase in gamma-amino-n-butyric acid input from the striatum and globus pallidus, which are activated during dopamine receptor blockade. As substantia nigra pars reticulata neurons are autoactive and resistant to tonic increases in gamma-amino-n-butyric acid input, changes in their responsiveness to phasic gamma-amino-n-butyric acid inputs, not tonic increase discharge rate, may underlie movement disturbance following dopamine deficit. |
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Authors:
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François Windels; Eugene A Kiyatkin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Neuroreport Volume: 17 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-22 Completed Date: 2006-09-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1071-5 Citation Subset: IM |
Affiliation:
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Cellular Neurobiology Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects,
physiology* Animals Benzazepines / pharmacology Dopamine Antagonists / pharmacology Dose-Response Relationship, Drug Drug Interactions Male Neurons / drug effects, physiology* Rats Rats, Long-Evans Receptors, Dopamine / physiology* Salicylamides / pharmacology Substantia Nigra / cytology* gamma-Aminobutyric Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Dopamine Antagonists; 0/Receptors, Dopamine; 0/Salicylamides; 56-12-2/gamma-Aminobutyric Acid; 84226-12-0/eticlopride |
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