Document Detail

Stability studies of the metabolites of nitrofuran antibiotics during storage and cooking.
MedLine Citation:
PMID:  17691006     Owner:  NLM     Status:  MEDLINE    
Nitrofuran antibiotics cannot be used in food production within the European Union because of their potential health risks to consumers. The recent discovery of their widespread use in global food industries and the finding of semicarbazide in baby food as a result of packaging contamination have focused attention on the toxicity and stability of these drugs and their metabolites. The stability of the nitrofuran marker residues 3-amino-2-oxazolidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ), 1-aminohydantoin (AHD) and semicarbazide (SEM) were tested. Muscle and liver of nitrofuran treated pigs were cooked by frying, grilling, roasting and microwaving. Between 67 and 100% of the residues remained after cooking, demonstrating that these metabolites are largely resistant to conventional cooking techniques and will continue to pose a health risk. The concentration of metabolites in pig muscle and liver did not drop significantly during 8 months of storage at -20 degrees C. Metabolite stock and working standard solutions in methanol were also stable for 10 months at 4 degrees C. Only a 10 ng ml(-1) solution of SEM showed a small drop in concentration over this extended storage period.
K M Cooper; D G Kennedy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives and contaminants     Volume:  24     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  935-42     Citation Subset:  IM    
Department of Veterinary Science, Queen's University Belfast, Belfast, UK.
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MeSH Terms
Anti-Infective Agents, Urinary / metabolism*
Carcinogens / analysis
Cookery / methods
Drug Stability
Food Contamination
Food Handling / methods*
Hydantoins / analysis
Liver / metabolism
Meat / analysis
Morpholines / analysis
Muscles / metabolism
Nitrofurans / metabolism*
Oxazolidinones / analysis
Refrigeration / methods
Semicarbazides / analysis
Reg. No./Substance:
0/1-aminohydantoin; 0/3-amino-5-morpholinomethyl-2-oxazolidinone; 0/Anti-Infective Agents, Urinary; 0/Carcinogens; 0/Hydantoins; 0/Morpholines; 0/Nitrofurans; 0/Oxazolidinones; 0/Semicarbazides; 57-56-7/carbamylhydrazine; 80-65-9/3-amino-2-oxazolidinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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