| Stability studies of the metabolites of nitrofuran antibiotics during storage and cooking. | |
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MedLine Citation:
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PMID: 17691006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrofuran antibiotics cannot be used in food production within the European Union because of their potential health risks to consumers. The recent discovery of their widespread use in global food industries and the finding of semicarbazide in baby food as a result of packaging contamination have focused attention on the toxicity and stability of these drugs and their metabolites. The stability of the nitrofuran marker residues 3-amino-2-oxazolidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ), 1-aminohydantoin (AHD) and semicarbazide (SEM) were tested. Muscle and liver of nitrofuran treated pigs were cooked by frying, grilling, roasting and microwaving. Between 67 and 100% of the residues remained after cooking, demonstrating that these metabolites are largely resistant to conventional cooking techniques and will continue to pose a health risk. The concentration of metabolites in pig muscle and liver did not drop significantly during 8 months of storage at -20 degrees C. Metabolite stock and working standard solutions in methanol were also stable for 10 months at 4 degrees C. Only a 10 ng ml(-1) solution of SEM showed a small drop in concentration over this extended storage period. |
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Authors:
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K M Cooper; D G Kennedy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Food additives and contaminants Volume: 24 ISSN: 0265-203X ISO Abbreviation: Food Addit Contam Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-10 Completed Date: 2008-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500474 Medline TA: Food Addit Contam Country: England |
Other Details:
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Languages: eng Pagination: 935-42 Citation Subset: IM |
Affiliation:
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Department of Veterinary Science, Queen's University Belfast, Belfast, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents, Urinary / metabolism* Carcinogens / analysis Cookery / methods Drug Stability Food Contamination Food Handling / methods* Hydantoins / analysis Liver / metabolism Meat / analysis Morpholines / analysis Muscles / metabolism Nitrofurans / metabolism* Oxazolidinones / analysis Refrigeration / methods Semicarbazides / analysis Swine |
| Chemical | |
Reg. No./Substance:
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0/1-aminohydantoin; 0/3-amino-5-morpholinomethyl-2-oxazolidinone; 0/Anti-Infective Agents, Urinary; 0/Carcinogens; 0/Hydantoins; 0/Morpholines; 0/Nitrofurans; 0/Oxazolidinones; 0/Semicarbazides; 57-56-7/carbamylhydrazine; 80-65-9/3-amino-2-oxazolidinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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