Document Detail


Stability of parenteral solutions of tobramycin sulfate.
MedLine Citation:
PMID:  242216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stability and physical compatibility of tobramycin sulfate in commonly used intravenous fluids were evaluated; in addition, pH values were obtained on 1 mg/ml tobramycin solutions, and microbiological potencies were obtained on 1 mg/ml and 0.2 mg/ml concentrations for 24- and 48-hour periods at 25 C. Most solutions were stable for 48 hours at room temperature. However, it is recommended that solutions of tobramycin sulfate be discarded after 24 hours to minimize the potential for inadvertent introduction of microorganisms during manipulations in the hospital environment.
Authors:
R F Bergstrom; A L Fites; J W Lamb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hospital pharmacy     Volume:  32     ISSN:  0002-9289     ISO Abbreviation:  Am J Hosp Pharm     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-01-23     Completed Date:  1976-01-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370474     Medline TA:  Am J Hosp Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  887-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents*
Biological Assay
Drug Incompatibility
Drug Stability
Heparin
Hydrogen-Ion Concentration
Infusions, Parenteral
Lactams
Solubility
Time Factors
Tobramycin*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Lactams; 32986-56-4/Tobramycin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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