Document Detail


Stability of the nucleic acids of L cells after infection with the meningopneumonitis agent.
MedLine Citation:
PMID:  5724971     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stability of host nucleic acids in L cells infected with Chlamydia psittaci (strain meningopneumonitis) was studied. The L cells were prelabeled with either (32)P-orthophosphate, (3)H-uridine, or (3)H-thymidine. After infection, the redistribution of each label among the different fractions of host and parasite was quantitatively determined and compared. There were no signs of accelerated degradation of host nucleic acid as the consequence of meningopneumonitis infection. Comparison of the specific activities of the meningopneumonitis nucleic acids with that of the acid-soluble fraction of host cell cytoplasm suggested that the major source of precursors for parasite nucleic acid synthesis was the common cytoplasmic pool of the infected host cell.
Authors:
H S Lin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  96     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1968 Dec 
Date Detail:
Created Date:  1969-01-31     Completed Date:  1969-01-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2049-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chlamydia / metabolism*
Cytoplasm
DNA / metabolism*
DNA, Bacterial / biosynthesis
L Cells (Cell Line)*
Phosphates / metabolism
Phosphorus Isotopes
RNA / metabolism*
RNA, Bacterial / biosynthesis
Thymidine / metabolism
Tritium
Uridine / metabolism
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/Phosphates; 0/Phosphorus Isotopes; 0/RNA, Bacterial; 10028-17-8/Tritium; 50-89-5/Thymidine; 58-96-8/Uridine; 63231-63-0/RNA; 9007-49-2/DNA
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