Document Detail


Stability of a novel dithranol ointment formulation, containing ascorbyl palmitate as an anti-oxidant.
MedLine Citation:
PMID:  2089049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An emulsifying ointment-based dithranol formulation is described which was, with the addition of 0.1% w/w ascorbyl palmitate, stable for 52 weeks at room temperature. This is in contrast to the more conventionally used dithranol in Lassar's paste, which is stable for only 4 weeks at room temperature. An emulsifying ointment-based paste was additionally more convenient to use since it was easier to apply and remove.
Authors:
P J Weller; C M Newman; K R Middleton; S M Wicker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  15     ISSN:  0269-4727     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-05-30     Completed Date:  1991-05-30     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  IM    
Affiliation:
Pharmacy Department, Northwick Park Hospital, Harrow, Middlesex, U.K.
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MeSH Terms
Descriptor/Qualifier:
Anthralin / administration & dosage*
Antioxidants*
Ascorbic Acid / analogs & derivatives*
Drug Stability
Ointments
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Ointments; 137-66-6/6-O-palmitoylascorbic acid; 480-22-8/Anthralin; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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