Document Detail

Stability of leukemia-associated aberrant immunophenotypes in patients with acute myeloid leukemia between diagnosis and relapse: comparison with cytomorphologic, cytogenetic, and molecular genetic findings.
MedLine Citation:
PMID:  15468339     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Multiparameter flow cytometry is increasingly used to monitor minimal residual disease in patients with acute myeloid leukemia to identify leukemic cells by leukemia-associated aberrant immunophenotypes (LAIPs). Changes in LAIPs during the course of the disease may be a limitation for this approach. METHODS: We analyzed 49 patients at diagnosis and relapse by flow cytometry, cytomorphology, cytogenetics, and molecular genetics. RESULTS: In 37 patients (76%), at least one LAIP detectable at diagnosis was present at relapse; in 12 patients (24%), none of the original LAIPs were present in at least 1% of bone marrow cells. Three groups were identified: no change in LAIPs, partial changes in LAIPs, and complete change in LAIPs. There were significant differences across these groups with regard to changes in cytomorphology (11%, 40%, and 58% of all cases, respectively; P = 0.007), cytogenetics (15%, 20%, and 25%; not significant), and molecular genetics (18%, 0, and 86%; P = 0.002). CONCLUSIONS: These data indicate that, in a subset of patients with acute myeloid leukemia, the disease is biologically different at relapse; therefore, monitoring of minimal residual disease is difficult to accomplish. In most patients with acute myeloid leukemia, multiparameter flow cytometry may be used to monitor minimal residual disease.
Daniela Voskova; Claudia Schoch; Susanne Schnittger; Wolfgang Hiddemann; Torsten Haferlach; Wolfgang Kern
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytometry. Part B, Clinical cytometry     Volume:  62     ISSN:  1552-4949     ISO Abbreviation:  Cytometry B Clin Cytom     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-29     Completed Date:  2005-03-03     Revised Date:  2009-12-11    
Medline Journal Info:
Nlm Unique ID:  101235690     Medline TA:  Cytometry B Clin Cytom     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-38     Citation Subset:  IM    
Copyright Information:
(c) 2004 Wiley-Liss, Inc.
Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
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MeSH Terms
Aged, 80 and over
Bone Marrow Cells / classification,  immunology,  pathology
Flow Cytometry* / methods
Immunoenzyme Techniques
Immunophenotyping / methods*
Leukemia, Myeloid, Acute / genetics,  immunology*,  pathology
Middle Aged
Neoplasm Recurrence, Local / genetics,  immunology*,  pathology
Neoplasm, Residual / genetics,  immunology*,  pathology

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