| Stability-indicating HPLC assays for the determination of piritramide and droperidol in PCA solution. | |
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MedLine Citation:
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PMID: 21366644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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WHAT IS KNOWN AND OBJECTIVE: A mixture of morphine and droperidol is a well-established antiemetic for reducing the risk of postoperative nausea and vomiting. A mixture of piritramide and droperidol has not yet been evaluated in this context. Our objectives were to develop a high-performance liquid chromatographic assay for piritramide and droperidol in 0·9% saline, and to establish their stability under defined storage conditions. METHODS: The separation and assay of both drugs were attempted by high performance liquid chromatography (HPLC) using a RP-select B column and a mobile phase of 57:43% v/v methanol-monosodium phosphate solution 0·05 M at a flow rate of 1·2 mL/min. UV detection at 205 and 246 nm for piritramide and droperidol were used, respectively. RESULTS AND DISCUSSION: The HPLC method was successful. Linearity was shown for piritramide from 0·075 to 0·013 mg/mL and for droperidol from 0·8 to 0·2 mg/mL. The intra- and inter-day relative standard deviation (RSD, %) was 0·27% and 0·54% for piritramide and droperidol, respectively. The two drugs were stable for at least 72 h when stored under ambient light at room temperature. WHAT IS NEW AND CONCLUSION: Seventy-five milligrams piritramide and 2·5 mg droperidol diluted to 50 ml with 0·9% saline should be suitable for clinical use. At this dilution, a Dipidolor(®) and Xomolix(®), mixture, was stable when stored under ambient light exposure at room temperature for at least 72 h. |
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Authors:
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S Selbach; W E Diederich; S Fett; D Fründ; T Koch; L H J Eberhart |
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Publication Detail:
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Type: Journal Article Date: 2010-08-13 |
Journal Detail:
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Title: Journal of clinical pharmacy and therapeutics Volume: 36 ISSN: 1365-2710 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-03 Completed Date: 2011-09-19 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
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Languages: eng Pagination: 161-5 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia, Patient-Controlled* Analgesics, Opioid / analysis* Antiemetics / analysis* Chromatography, High Pressure Liquid Droperidol / analysis* Drug Stability Humans Pharmaceutical Solutions / analysis Pirinitramide / analysis* Postoperative Nausea and Vomiting / chemically induced, drug therapy*, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Antiemetics; 0/Pharmaceutical Solutions; 302-41-0/Pirinitramide; 548-73-2/Droperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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