Document Detail


Stability of ganciclovir sodium and amino acids in parenteral nutrient solutions.
MedLine Citation:
PMID:  8017417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stability of ganciclovir sodium and amino acids in parenteral nutrient solutions was studied. Three admixtures of ganciclovir sodium plus parenteral nutrient solution were prepared, one containing ganciclovir sodium 0.83 mg/mL, 1% amino acids, and 10% dextrose injection; one containing ganciclovir sodium 1.4 mg/mL, 2.5% amino acids, and 10% dextrose injection; and one containing ganciclovir sodium 1.4 mg/mL, 5% amino acids, and 25% dextrose injection. The solutions were visually inspected for precipitates, color change, and gas formation and were tested for pH. High-performance liquid chromatography was used to measure the concentration of ganciclovir and 16 amino acids in each admixture immediately and one, two, and three hours after preparation. There was no evidence of visual incompatibility in any of the admixtures, and pH did not vary appreciably during the study. The mean ganciclovir sodium concentration remaining was greater than 100% of the initial concentration for all the admixtures at one, two, and three hours. The mean amino acid concentration remaining in the admixtures with 2.5% or 5.0% amino acids was greater than 90% of the initial concentration for each amino acid at one, two, and three hours. The mean amino acid concentration remaining in the admixture with 1% amino acids was greater than 90% of the initial level at one and two hours. Ganciclovir sodium 0.83 mg/mL was stable for at least three hours in parenteral nutrient solution with 1% amino acids, and ganciclovir sodium 1.4 mg/mL was stable for at least three hours in admixtures with 2.5% or 5% amino acids.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
C E Johnson; P A Jacobson; E Chan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hospital pharmacy     Volume:  51     ISSN:  0002-9289     ISO Abbreviation:  Am J Hosp Pharm     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-07-27     Completed Date:  1994-07-27     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0370474     Medline TA:  Am J Hosp Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Affiliation:
College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis,  chemistry*
Chromatography, High Pressure Liquid
Drug Incompatibility
Drug Stability
Food, Formulated
Ganciclovir / analysis,  chemistry*
Hydrogen-Ion Concentration
Parenteral Nutrition
Chemical
Reg. No./Substance:
0/Amino Acids; 82410-32-0/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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