Document Detail

Stability of free beta-hCG in the routine screening of Down syndrome in the first trimester of pregnancy.
MedLine Citation:
PMID:  19548594     Owner:  NLM     Status:  MEDLINE    
Stability of free beta-human chorionic gonadotropin in maternal blood upon storage at ambient and refrigerator temperatures as well as stability under conditions simulating postal transport were studied. A group of 26 women in the first trimester of pregnancy were included in the study, blood samples were taken during the routine check-up. Blood samples were aliquoted stored in different conditions that should mimic the transportation and then analysed for free beta-hCG. No significant differences were found in the free beta-hCG levels in samples after 24 and 48 hours resp., stored in refrigerator (2-8 degrees C) without separation. In samples stored in laboratory temperature without separation the average concentration increased from 11 to 20%. Six blood samples were stored at 35 degrees C for 5 hours and then in laboratory temperature. In this group the average increase of results was from 14.3% to 132.2%. Separation of the sera for Down syndrome screening in 4 hours after withdrawal is necessary. Cooling during any storage, including transportation is highly recommended as the preanalytical phase has a high impact for the analysis.
D Springer; T Zima; L Arnostová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prague medical report     Volume:  109     ISSN:  1214-6994     ISO Abbreviation:  Prague Med Rep     Publication Date:  2008  
Date Detail:
Created Date:  2009-06-24     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101227436     Medline TA:  Prague Med Rep     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  134-41     Citation Subset:  IM    
Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Institute of Clinical Biochemistry and Laboratory Diagnostics, Prague, Czech Republic.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood*
Down Syndrome / diagnosis*
Pregnancy Trimester, First
Prenatal Diagnosis*
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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