Document Detail


Stability of dantrolene oral suspension prepared from capsules.
MedLine Citation:
PMID:  7876365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chemical stability of an extemporaneously compounded dantrolene oral suspension (5 mg/ml dantrolene sodium) in Syrup BP containing citric acid with and without methyl hydroxybenzoate preservative was studied on storage at 5, 25 and 40 degrees C for 150 days in high density polyethylene dispensing bottles. The amount of dantrolene free acid in suspension was monitored by a stability indicating HPLC assay. There was no significant decomposition of dantrolene under all storage conditions irrespective of the presence of preservative. The results show that the formulation of dantrolene oral suspension provides a convenient and stable dosage form for use in pediatric patients and in those unable to swallow capsules. It is recommended that the formulation be stored at room temperature and in the absence of microbiological testing a shelf-life of 30 days is proposed for the product prepared with preserved syrup.
Authors:
J P Fawcett; G Stark; I G Tucker; D J Woods
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  19     ISSN:  0269-4727     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-06     Completed Date:  1995-04-06     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
Affiliation:
School of Pharmacy, University of Otago, Dunedin, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Capsules
Dantrolene / chemistry*
Drug Stability
Drug Storage
Neuromuscular Agents / chemistry
Suspensions
Chemical
Reg. No./Substance:
0/Capsules; 0/Neuromuscular Agents; 0/Suspensions; 7261-97-4/Dantrolene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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