| Stability of attenuated live virus rabies vaccine in baits targeted to wild foxes under operational conditions. | |
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MedLine Citation:
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PMID: 11360859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The viability of an attenuated live virus rabies vaccine in a bait targeted to red foxes was examined under various operational conditions in a series of experiments in Ontario. The virus was relatively stable over a 28-day period in the field, losing a mean 0.5, s = 0.2 log10 of virus titer. The micro-environment into which the bait was placed (open cultivated field, grassy meadow, wooded grove, sun or shade) did not make an appreciable difference in the viability of the virus. There was no significant difference (P < or = 0.05) between mean ambient temperatures and the temperature of fluids in blister packs of baits placed in sun or shade. Sixty-three percent of foxes fed baits exposed to sun and shade conditions for 21 days (titer 10(6.2) tissue culture infective doses per 1 mL) developed rabies virus-neutralizing antibodies. Storage of vaccine baits at -30 degrees C prior to bait distribution was important in maintaining virus viability. |
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Authors:
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K F Lawson; P Bachmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian veterinary journal. La revue vétérinaire canadienne Volume: 42 ISSN: 0008-5286 ISO Abbreviation: Can. Vet. J. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-21 Completed Date: 2001-08-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0004653 Medline TA: Can Vet J Country: Canada |
Other Details:
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Languages: eng Pagination: 368-74 Citation Subset: IM |
Affiliation:
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Ontario Ministry of Natural Resources, Trent University, P.O. Box 4840, Peterborough, Ontario K9J 8N8. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Stability Foxes* Rabies / prevention & control, veterinary* Rabies Vaccines / administration & dosage*, radiation effects, standards Rabies virus / immunology, physiology, radiation effects Sunlight / adverse effects Temperature Time Factors Vaccination / methods, standards, veterinary* Vaccines, Attenuated / administration & dosage, radiation effects, standards |
| Chemical | |
Reg. No./Substance:
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0/Rabies Vaccines; 0/Vaccines, Attenuated |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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