Document Detail


Stability of antibiotics and chemotherapeutics in agar plates.
MedLine Citation:
PMID:  5485725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stability of chemotherapeutic agents incorporated into agar plates was studied by comparison of minimum inhibitory concentrations on fresh and stored plates and by direct bioassay of the chemotherapeutic agar plates. Plates were stored in sealed bags at 4 C. No loss of bioactivity was demonstrated after 30 days of storage in plates containing methicillin, erythromycin, cephalothin, tetracycline, chloramphenicol, kanamycin, streptomycin, polymyxin B, or nalidixic acid. Penicillin G, ampicillin, and nitrofurantoin showed statistically significant losses of activity after 4 weeks. None of the chemotherapeutics tested showed significant loss in activity after 1 week.
Authors:
K J Ryan; G M Needham; C L Dunsmoor; J C Sherris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied microbiology     Volume:  20     ISSN:  0003-6919     ISO Abbreviation:  Appl Microbiol     Publication Date:  1970 Sep 
Date Detail:
Created Date:  1971-01-28     Completed Date:  1971-01-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605802     Medline TA:  Appl Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Agar*
Anti-Bacterial Agents* / pharmacology
Bacteria / drug effects
Drug Stability*
Temperature
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 9002-18-0/Agar
Comments/Corrections

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