Document Detail


Stability of aneuploidy rate in polar bodies in two cohorts from the same patient.
MedLine Citation:
PMID:  18681995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate the stability of the aneuploidy rate of the first polar body. Knowing the stability of the oocyte aneuploidy rate for each patient would allow the first analysis to be used as a prognostic tool for further attempts at intracytoplasmic sperm injection (ICSI). After a first unsuccessful ICSI attempt with preconceptional screening, 24 women underwent a second attempt. First polar body aneuploidy rates were compared in the course of two successive ovarian stimulations. The first polar body was biopsied after laser dissection of the zona pellucida and five chromosomes were analysed using the MultiVysion polar body multicolour probe panel. A total of 200 polar bodies were analysed; 91 and 109 in the first and second ICSI attempts, respectively. The total aneuploidy rate was identical in the first and second attempts; 44.0% (40/91) and 44.0% (48/109), respectively. The first evaluation of the aneuploidy rate was statistically (P = 0.0007) correlated with the second, with a correlation coefficient, r = 0.707. The stability of the aneuploidy rate in different cohorts from the same patient, if confirmed in a larger series, makes this parameter a useful tool for counselling couples.
Authors:
F Vialard; D Molina Gomes; I Hammoud; M Bergere; R Wainer; M Bailly; R Lombroso; J Selva
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  17     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-06     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM    
Affiliation:
Department of Reproductive Biology, Université Versailles-St Quentin, CHI Poissy-Saint Germain, 10 rue du Champ Gaillard, 78303 Poissy cedex, France. fvialard@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aneuploidy*
Cleavage Stage, Ovum
Cohort Studies
Female
Humans
In Situ Hybridization, Fluorescence
Infertility, Female / diagnosis,  etiology,  genetics,  therapy
Male
Maternal Age
Oocytes / metabolism*,  physiology,  ultrastructure*
Pregnancy
Preimplantation Diagnosis* / methods
Prognosis
Reproducibility of Results
Risk Factors
Sperm Injections, Intracytoplasmic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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