Document Detail

Stability of admixtures of pethidine and metoclopramide in aqueous solution, 5% dextrose and 09% sodium chloride.
MedLine Citation:
PMID:  19160718     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the stability of admixtures of pethidine and metoclopramide in aqueous solution, 0.9% sodium chloride and 5% dextrose preparations. METHOD: Aqueous mixtures of 1 ml of 50 mg/ml pethidine with 2ml of 5 mg/ml metoclopramide were prepared in plastic syringes, while the 0.9% sodium chloride and 5% dextrose admixtures, each containing 7.35 mg/ml of pethidine and 0.15 mg/ml of metoclopramide, were prepared in infusion bags. The preparations were stored under light and dark conditions at 32 degrees C for 48 h. Samples were collected at 0, 0.5, 1, 2, 4, 6, 8, 24, 32 and 48 h. A high-performance liquid chromatographic method was developed to separate and quantify both drugs. RESULTS: All preparations were found to be physically and chemically stable for at least 48h, as concentration changes were within 10% of their initial level, with no development of haze, precipitate or colour. Light appeared to have a negligible effect. Although pH changes were observed, they were inconsistent and were within the ranges in which the drugs are expected to remain stable. Pethidine and metoclopramide admixtures can, therefore, on stability grounds be used for the concomitant management of pain, nausea and vomiting.
M M Hor; S Y Chan; K L Yow; L Y Lim; E Chan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  22     ISSN:  0269-4727     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:    1997 Oct-Dec
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  IM    
Department of Pharmacy, National University of Singapore, 10 Kent Ridge Crescent, Singapore.
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MeSH Terms
Analgesics, Opioid / chemistry*
Antiemetics / chemistry*
Chromatography, High Pressure Liquid
Drug Combinations
Drug Packaging
Drug Stability
Drug Storage
Glucose / analysis*
Hydrogen-Ion Concentration
Infusions, Intravenous
Meperidine / analysis*
Metoclopramide / chemistry*
Polyvinyl Chloride
Sodium Chloride / analysis*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Antiemetics; 0/Drug Combinations; 0/Solutions; 364-62-5/Metoclopramide; 50-99-7/Glucose; 57-42-1/Meperidine; 7647-14-5/Sodium Chloride; 9002-86-2/Polyvinyl Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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