Document Detail

Stability of adherence to highly active antiretroviral therapy over time among clients enrolled in the treatment adherence demonstration project.
MedLine Citation:
PMID:  12869837     Owner:  NLM     Status:  MEDLINE    
Adherence to antiretroviral medications is essential to therapeutic success. Many published studies have investigated the degree of adherence or nonadherence, but sample sizes have generally been small, and adherence has seldom been viewed as a longitudinal process. This paper investigates the stability of adherence over time among HIV-infected individuals attending adherence support programs in New York State. The study cohort consists of 435 clients who were on HAART at baseline and who completed at least 2 follow-up interviews. Although cross-sectional nonadherence did not exceed 35%, nonadherence reached 54% when considered across all 3 interviews. Analysis of transition matricies revealed moderate stability in adherence over time (e.g., first follow-up adherence was 81.0% for clients adherent at baseline, compared with 58.3% for clients nonadherent at baseline). Second-order transition matricies offered additional predictive utility. Multivariate results indicated that, for some, it was the transition from a desirable to an undesirable state (e.g., from no illicit drug use to illicit drug use) that increased the likelihood of nonadherence, rather than the presence of these characteristics over time. Findings illustrate the importance of multiple, periodic assessments of adherence and the need to consider strategies to increase stability in the factors affecting adherence to HAART.
James Tesoriero; Tyler French; Linda Weiss; Mark Waters; Ruth Finkelstein; Bruce Agins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  33     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-18     Completed Date:  2004-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  484-93     Citation Subset:  IM; X    
AIDS Institute, New York State Department of Health, Menands, New York 12204, USA.
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MeSH Terms
Antiretroviral Therapy, Highly Active*
HIV Infections / drug therapy*
Longitudinal Studies
Patient Compliance*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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