Document Detail

Stability of acetylsalicylic acid in divided powders in the presence of aminophenazone.
MedLine Citation:
PMID:  432254     Owner:  NLM     Status:  MEDLINE    
The combination of acetylsalicylic acid with aminophenazone, often prescribed in divided powders, is considered to be incompatible. High performance liquid chromatography was applied to determine the content of salicylic acid which is the main known product from the decomposition of acetylsalicylic acid. The analysis of model samples containing a 1:1 (by weight) mixture of acetylsalicylic acid and aminophenazone, after having been stored under usual conditions in starch capsules, showed that the decomposition of acetylsalicylic acid into salicylic acid did not exceed 0.8% even after ten weeks.
J Subert; K Slais
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  34     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-06-26     Completed Date:  1979-06-26     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
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MeSH Terms
Aminopyrine / analysis*
Aspirin / analysis*
Chromatography, High Pressure Liquid
Drug Stability
Reg. No./Substance:
0/Powders; 50-78-2/Aspirin; 58-15-1/Aminopyrine

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