Document Detail


Stability of acetylsalicylic acid in divided powders in the presence of aminophenazone.
MedLine Citation:
PMID:  432254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The combination of acetylsalicylic acid with aminophenazone, often prescribed in divided powders, is considered to be incompatible. High performance liquid chromatography was applied to determine the content of salicylic acid which is the main known product from the decomposition of acetylsalicylic acid. The analysis of model samples containing a 1:1 (by weight) mixture of acetylsalicylic acid and aminophenazone, after having been stored under usual conditions in starch capsules, showed that the decomposition of acetylsalicylic acid into salicylic acid did not exceed 0.8% even after ten weeks.
Authors:
J Subert; K Slais
Related Documents :
15913294 - Lipoxygenase inhibitory activity of anacardic acids.
6715524 - Disk diffusion susceptibility testing of ticarcillin plus clavulanic acid.
8117314 - Studies on the reactivity of acyl glucuronides--vii. salicyl acyl glucuronide reactivit...
18652434 - Structure, energetics, and reactivity of boric acid nanotubes: a molecular tailoring ap...
3035704 - Eicosapentaenoic- and arachidonic acid metabolism in isolated liver cells.
17355494 - A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophyl...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  34     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-06-26     Completed Date:  1979-06-26     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aminopyrine / analysis*
Aspirin / analysis*
Chromatography, High Pressure Liquid
Drug Stability
Powders
Chemical
Reg. No./Substance:
0/Powders; 50-78-2/Aspirin; 58-15-1/Aminopyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physico-chemical analysis of systems with a main component acetylsalicylic acid in ethanol-water mix...
Next Document:  Interactions between macromolecular adjuvants and drugs. Part 16: Effects of human serum albumin and...