Document Detail


Stability of Polyphenols Epigallocatechin Gallate and Pentagalloyl Glucose in a Simulated Digestive System.
MedLine Citation:
PMID:  23028206     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polyphenols found in foods and beverages are under intense scrutiny for their potential beneficial effects on human health. We examined the stability of two bioactive polyphenols, epigallocatechin-O-gallate (EGCg) and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG), in a model digestive system at low oxygen tension with and without added digestive components and foods. Both compounds were stable at pH values of 5-6 and below, indicating gastric stability. Both compounds decomposed at pH 7.0. PGG was stabilized in a model system containing pepsin, pancreatin, bile and lipase, and/or baby food, but was not stabilized by dry cereal. EGCg was not stabilized by the addition of any biomolecule. The effects of polyphenols on human health should be evaluated in the context of their stability in the digestive tract with and without added digestive components and/or food.
Authors:
Melanie A Krook; Ann E Hagerman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-4
Journal Detail:
Title:  Food research international (Ottawa, Ont.)     Volume:  49     ISSN:  0963-9969     ISO Abbreviation:  Food Res. Int.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9210143     Medline TA:  Food Res Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  112-116     Citation Subset:  -    
Affiliation:
Department of Chemistry and Biochemistry, Miami University, 651 E. High St., Oxford OH 45056 U.S.A.
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