Document Detail

St. Jude Medical prosthesis: valve-related deaths and complications.
MedLine Citation:
PMID:  3496058     Owner:  NLM     Status:  MEDLINE    
Despite the hemodynamic improvement in cardiac valve prostheses, valve-related deaths and complications have remained a substantial source of morbidity and mortality. This follow-up study was carried out in April, 1986, in a group of 816 patients who received 876 St. Jude Medical prostheses between October, 1977, and October, 1984. One hundred fifty-five patients (37%) of the 422 having aortic valve replacement (AVR) and 88 (29%) of the 300 having mitral valve replacement (MVR) had concomitant coronary artery bypass grafting, and 94 patients (12%) had miscellaneous procedures performed in addition to valve replacement. Sixty-three patients died within the operative period, an operative mortality of 7.7%. Follow-up was complete for 98% of the patients; the mean follow-up was 42 months. At that time, 87 more patients had died, a late mortality of 11.9%. There were 13 valve-related deaths (4 in the AVR group, 7 in the MVR group, and 2 in the miscellaneous group); the causes of death were thromboembolism (7), anticoagulant-related hemorrhage (2), valve thrombosis (2), prosthetic valve endocarditis (1), and perivalvular leak (1). There were 37 thromboembolic episodes (1.78/100 patient-years) and 67 anticoagulant-related hemorrhages (3.22/100 patient-years), 46% of which necessitated transfusion. The incidence of valve thrombosis was 0.6% (4 patients). Perivalvular leak and prosthetic valve endocarditis occurred in 7 patients (1.0%) and 5 patients (0.7%), respectively. Reoperation was carried out in 6 patients (0.8%), but only for perivalvular leak. There were no deaths, no complications, and no clinical evidence of malfunction of the prosthetic valve.(ABSTRACT TRUNCATED AT 250 WORDS)
K V Arom; D M Nicoloff; T E Kersten; W G Lindsay; W F Northrup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  43     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-08     Completed Date:  1987-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  591-8     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Aortic Valve
Child, Preschool
Coronary Artery Bypass / adverse effects,  mortality
Follow-Up Studies
Heart Valve Diseases / complications,  mortality,  surgery
Heart Valve Prosthesis / adverse effects,  mortality*
Hemorrhage / epidemiology,  mortality
Middle Aged
Mitral Valve
Postoperative Complications / epidemiology,  mortality*
Thromboembolism / epidemiology,  mortality

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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