Document Detail


The Sri Lankan Twin Registry: 2012 Update.
MedLine Citation:
PMID:  23302519     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The Sri Lankan Twin Registry (SLTR), established in 1997, is a unique resource for twin and genetic research in a low- and middle-income country (LMIC). It comprises of a volunteer cohort of 14,120 twins (7,060 pairs) and 119 sets of triplets, and a population-based cohort of 19,040 (9,520 pairs) twins and 89 sets of triplets. Several studies have been conducted using this registry, including the Colombo Twin and Singleton Study (CoTaSS 1; 4,387 twins, 2,311 singletons), which have explored the prevalence and heritability of a range of psychiatric disorders as well as gene-environmental interplay. Currently, a follow-up study (CoTaSS 2) of the same cohort is underway, looking at the prevalence and interrelationship of key cardiovascular and metabolic risk markers (e.g., metabolic syndrome). A significant feature of CoTaSS 2 is the establishment of a biobank. Current SLTR work is extending beyond mental health and the interface between mental and physical health to new horizons, extending collaborations with the wider global twin research community. Ethics and governance have been given special emphasis in the initiative. Capacity building and public engagement are two crucial components. Establishment of a state-of-the-art genetic laboratory was a major accomplishment. SLTR is a classic showcase of successful North-South partnership in building a progressive research infrastructure in a LMIC.
Authors:
Athula Sumathipala; Sisira Siribaddana; Mathew Hotopf; Peter McGuffin; Nick Glozier; Harriet Ball; Yulia Kovas; Fruhling Rijsdijk; Lalani Yatawara; Carmine Pariante; Helena Zavos; Chesmal Siriwardhana; Gayani Pannala; Kaushalya Jayaweera; Anushka Adikari; Dinesha Gunewardane
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  -     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-6     Citation Subset:  -    
Affiliation:
Institute for Research & Development, Colombo, Sri Lanka.
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