| Src and the control of cell division. | |
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MedLine Citation:
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PMID: 8593169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The finely tuned mechanisms that control cell cycle progression go awry in cancer, pointing to proto-oncogene products as important players in cell-cycle regulation. One such proto-oncoprotein, c-Src, has previously been directly implicated, based on its requirement for growth factor-stimulated DNA synthesis. Roche et al. have now shown that c-Src or its close relatives are also required for cell division to occur. The demonstration of essential functions for the Src family at multiple points in the cell cycle raises important questions about the normal and transforming activities of these and other proto-oncoproteins. |
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Authors:
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S J Taylor; D Shalloway |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: BioEssays : news and reviews in molecular, cellular and developmental biology Volume: 18 ISSN: 0265-9247 ISO Abbreviation: Bioessays Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-04-01 Completed Date: 1996-04-01 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8510851 Medline TA: Bioessays Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 9-11 Citation Subset: IM |
Affiliation:
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Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14851, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anura Cell Cycle / genetics Cell Division / genetics* G2 Phase Gene Expression Regulation Genes, src* Humans Mice Multigene Family* Phosphorylation Protein Processing, Post-Translational Protein-Tyrosine Kinases / genetics, physiology Proto-Oncogene Proteins / physiology Proto-Oncogene Proteins pp60(c-src) / physiology* Xenopus laevis src Homology Domains / physiology |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/Proto-Oncogene Proteins pp60(c-src) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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