| Src, chemoresistance and epithelial to mesenchymal transition: are they related? | |
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MedLine Citation:
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PMID: 17351389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Src family of nonreceptor tyrosine kinases regulates numerous cellular processes, including proliferation, differentiation, migration, survival and angiogenesis. In solid tumors, Src is frequently aberrantly active, and promotes tumor progression and metastasis. Although multiple Src functions may contribute to metastasis, recently Src has been shown to play a role in epithelial to mesenchymal transition. Increased Src activity promotes this process and inhibition of Src suppresses epithelial to mesenchymal transition. Although the molecular events causing epithelial to mesenchymal transition are becoming well defined, the processes in tumor cells that trigger the onset of this phenotype remain unclear. Recent studies have associated epithelial to mesenchymal transition with the development of chemoresistance. Src has also been shown to be involved in chemoresistance of cancer cells. The activation of Src in chemoresistant cells is related to an increase in motility, invasiveness and detachment, all phenotypes characteristic both of Src activation and of epithelial to mesenchymal transition. This review focuses on upregulation of Src in cancer as it relates to chemoresistance and epithelial to mesenchymal transition. |
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Authors:
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Ami N Shah; Gary E Gallick |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Anti-cancer drugs Volume: 18 ISSN: 0959-4973 ISO Abbreviation: Anticancer Drugs Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-04-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9100823 Medline TA: Anticancer Drugs Country: England |
Other Details:
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Languages: eng Pagination: 371-5 Citation Subset: IM |
Affiliation:
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Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Resistance, Neoplasm / physiology* Humans Mesenchymal Stem Cells / physiology* Neoplasm Metastasis / physiopathology src-Family Kinases / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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T32 CA 09599/CA/NCI NIH HHS; U54 CA 090810/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.2/src-Family Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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