Document Detail

Squatting amplifies pulse pressure increase with disease duration in patients with type 1 diabetes.
MedLine Citation:
PMID:  17977932     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate pulse pressure changes according to duration of type 1 diabetes and to assess the influence of posture. RESEARCH DESIGN AND METHODS: We performed continuous measurement of blood pressure with a Finapres device during a 3 x 1 min posture test (standing, squatting, standing) in 159 type 1 diabetic patients divided into four groups according to diabetes duration (<or=10, 11-20, 21-30, and >30 years, groups 1-4, respectively) and compared the results with those of age-matched nondiabetic subjects. RESULTS: Pulse pressure progressively increased according to type 1 diabetes duration (P < 0.0001), especially in women, but not in age-matched nondiabetic subjects (NS). Pulse-pressure increase from group 1 to group 4 was amplified in the squatting position (from 50 +/- 17 to 69 +/- 14 mmHg) compared with standing (from 44 +/- 15 to 55 +/- 12 mmHg). CONCLUSIONS: Pulse pressure increases according to type 1 diabetes duration more in women than in men, and the squatting position sensitizes such pulse-pressure increase in both sexes.
Jean-Christophe Philips; Monique Marchand; André J Scheen
Publication Detail:
Type:  Journal Article     Date:  2007-10-31
Journal Detail:
Title:  Diabetes care     Volume:  31     ISSN:  1935-5548     ISO Abbreviation:  Diabetes Care     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-29     Completed Date:  2008-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-4     Citation Subset:  IM    
Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, Centre Hospitalier Universitaire Sart Tilman, University of Liége, Liège, Belgium.
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MeSH Terms
Age of Onset
Analysis of Variance
Blood Pressure / physiology*
Diabetes Mellitus, Type 1 / physiopathology*
Middle Aged
Monitoring, Ambulatory
Reference Values
Sex Characteristics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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