Document Detail

Squamous metaplasia of Paget's disease.
MedLine Citation:
PMID:  14723727     Owner:  NLM     Status:  MEDLINE    
A patient had triple extramammary Paget's disease of both axillary and genital regions. Right inguinal lymphadenopathy was found 1 year after excision of all the skin lesions. Excisional biopsy of the lymph node demonstrated a mixture of Paget cells and atypical squamoid cells with horn pearls suggestive of keratinization. The squamoid cells were positive for cytokeratin 10, a marker of suprabasal epidermis, and also positive for laminin gamma2 which is often expressed in invasive squamous cell carcinoma. The coexistence of these different cells within the same tumour island suggested that the squamoid cells derived from metaplasia of Paget cells.
T Miyakawa; Y Togawa; H Matushima; H Nakamura; N Kamada; Y Momota; N Tochigi; T Nikaido; H Shinkai; A Utani
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  29     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-15     Completed Date:  2004-03-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  IM    
Department of Dermatology, School of Medicine, Chiba University, 1-8-1 Inohana-cho, Chuo-ku, Chiba city 260-8670, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / pathology
Diagnosis, Differential
Genital Neoplasms, Male / pathology*
Lymphatic Metastasis / pathology
Metaplasia / pathology
Paget Disease Extramammary / pathology*
Scrotum / pathology*

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