Document Detail

Squamous cell carcinomas with single cell infiltration: a potential diagnostic pitfall and the utility of MNF116 and p63.
MedLine Citation:
PMID:  18333895     Owner:  NLM     Status:  MEDLINE    
Numerous variants of squamous cell carcinoma (SCC) have been described. We recently encountered four examples of SCC composed primarily of single, atypical cells that were cytokeratin (CK) MNF116-positive and p63-positive. One case was particularly difficult to diagnose as the single cells were obscured by a dense inflammatory infiltrate. We have also noted similar single cell infiltration toward the periphery of four additional cases of more typical SCC. These foci resemble the single tumor cells that may infiltrate at the borders of spindle cell and desmoplastic SCCs. CK MNF116 and p63 were useful in identifying each of these neoplasms. This single--cell pattern of SCC can easily be misdiagnosed, and CK MNF116 and/or p63 are diagnostically helpful in recognizing it.
Christine J Ko; Jennifer M McNiff; Earl J Glusac
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  35     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  353-7     Citation Subset:  IM    
Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / chemistry,  diagnosis*,  surgery
Keratins / analysis*
Membrane Proteins / analysis*
Middle Aged
Mohs Surgery
Neoplasm Invasiveness
Skin Neoplasms / chemistry,  diagnosis*,  surgery
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/CKAP4 protein, human; 0/Membrane Proteins; 0/Tumor Markers, Biological; 0/cytokeratin MNF116, human; 68238-35-7/Keratins

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