Document Detail

Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations.
MedLine Citation:
PMID:  11948119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The role of human papilloma virus (HPV) in the pathogenesis and biological behavior of tonsillar squamous cell carcinoma (TSCC) are areas of intense investigation. METHODS: This study used PCR analysis to identify HPV in paraffin-embedded tonsillar and nodal tissue from 52 patients with TSCC and 48 age (+/-5 year)/gender-matched controls with benign tonsillar hyperplasia. Results were correlated with HLA-DRB1 haplotype and clinical outcome. RESULTS: HPV was identified in 46% of patients with TSCC and 6% of controls. DNA sequencing showed the presence of HPV type 16 in 21 patients (40%) with TSCC. There was no statistically significant association between HLA-DRB1 expression and TSCC or HPV infection. Fifteen of 16 patients with HPV-positive TSCC with regional metastases had evidence of HPV in pathologically involved lymph nodes. In eight HPV 16-positive TSCC patients with lymph node metastasis, PCR testing identified HPV 16 in 17 of 23 histologically negative lymph nodes. Patients with HPV-positive TSCC without metastatic disease had no evidence of HPV in their lymphatic tissue. Clinically, HPV-associated carcinoma was present in younger patients in comparison with HPV-negative TSCC patients (mean age, 56.6 versus 66 years; P = 0.001). The odds for patients with HPV infection to develop TSCC were 18.2 times greater than for patients without HPV infection (95% confidence interval 4.6, 73.1). There was no statistically significant association between presence of HPV and cause-specific survival (hazard ratio = 2.5 for HPV negative versus positive; P = 0.26), after adjusting for age in a Cox proportional hazards regression analysis. CONCLUSION: HPV is an independent risk factor for TSCC. Identification of HPV in the histologically positive and negative lymph nodes of patients with HPV-positive TSCC/metastatic disease supports the role of HPV in the oncogenesis of TSCC.
Scott E Strome; Athanasia Savva; Anthony E Brissett; Bobbie S Gostout; Jean Lewis; Amy C Clayton; Renee McGovern; Amy L Weaver; David Persing; Jan L Kasperbauer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  8     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1093-100     Citation Subset:  IM    
Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Aged, 80 and over
Alcohol Drinking
Carcinoma, Squamous Cell / genetics,  pathology*,  virology
Case-Control Studies
DNA, Viral / genetics
Gene Expression Regulation, Neoplastic
HLA-DR Antigens / genetics
Lymphatic Metastasis
Middle Aged
Papillomaviridae / genetics
Papillomavirus Infections / genetics,  pathology,  virology
Risk Factors
Survival Analysis
Tonsillar Neoplasms / genetics,  pathology*,  virology
Tumor Virus Infections / genetics,  pathology,  virology
Reg. No./Substance:
0/DNA, Viral; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen

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