Document Detail

Squamous cell carcinoma of the skin with an unusual marker chromosome.
MedLine Citation:
PMID:  2461273     Owner:  NLM     Status:  MEDLINE    
Chromosome studies were undertaken on uncultured material from a primary anaplastic squamous cell carcinoma of the skin from a female aged 81. The modal chromosome number was 42. Four marker chromosomes were present in most metaphases: a der (1) which resulted in tetrasomy for most of 1q, a giant chromosome consisting of most of a chromosome 2 and 4q, a small metacentric which was probably an isochromosome for 4p or 5p, and a small chromosome, considered to be an 18q+. The latter was conspicuous in unbanded orcein-stained preparations owing to the presence of a virtually nonstaining region on its long arm. These findings are of interest in the light of the paucity of data on this type of tumour.
N B Atkin; M C Baker; I Petković
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytobios     Volume:  54     ISSN:  0011-4529     ISO Abbreviation:  Cytobios     Publication Date:  1988  
Date Detail:
Created Date:  1988-12-23     Completed Date:  1988-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207227     Medline TA:  Cytobios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, Great Britain.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology*
Chromosome Aberrations / pathology*
Chromosome Banding
Chromosome Disorders
Genetic Markers / analysis*
Skin Neoplasms / pathology*
Staining and Labeling
Reg. No./Substance:
0/Genetic Markers

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