Document Detail

Squamous cell carcinoma secondary to recessive dystrophic epidermolysis bullosa. A report of 4 patients with 17 primary cutaneous malignancies.
MedLine Citation:
PMID:  1560154     Owner:  NLM     Status:  MEDLINE    
Four patients with recessive dystrophic epidermolysis bullosa and 17 invasive primary cutaneous squamous cell carcinomas (SCCs) are presented. All skin cancers arose at the site of scarring due to recessive dystrophic epidermolysis bullosa. Three of 17 (18%) primary cutaneous SCCs recurred locally following initial treatment with either surgical excision or wide surgical excision. Patients with recessive dystrophic epidermolysis bullosa are more likely to develop SCCs of the extremities than nonimmunocompromised patients or patients with epidermodysplasia verruciformis. Like patients with epidermodysplasia verruciformis, patients with recessive dystrophic epidermolysis bullosa are likely to suffer from invasive and metastatic SCCs at a much younger age than nonimmunocompromised patients.
C Newman; R F Wagner; S K Tyring; G T Spigel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatologic surgery and oncology     Volume:  18     ISSN:  0148-0812     ISO Abbreviation:  J Dermatol Surg Oncol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-13     Completed Date:  1992-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707501     Medline TA:  J Dermatol Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
Department of Dermatology, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Carcinoma, Squamous Cell / etiology*,  pathology,  therapy
Cicatrix / complications,  pathology
Epidermolysis Bullosa Dystrophica / complications*,  genetics,  pathology
Genes, Recessive
Neoplasm Recurrence, Local
Skin Neoplasms / etiology*,  pathology,  therapy

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