Document Detail

Squamous carcinoma of the foot arising in association with long-standing verrucous hyperplasia in a patient with congenital lymphedema.
MedLine Citation:
PMID:  6540138     Owner:  NLM     Status:  MEDLINE    
A patient is reported with congenital lymphedema who developed a squamous cell carcinoma on his affected foot. Parallels are drawn between the development of a squamous cell carcinoma with condylomatous and spindle cell features arising in a setting of long-standing verrucous hyperplasia, as seen in this patient, and the well-recognized phenomenon of angiosarcoma occurring in areas of lymphangiomatous proliferation in patients with chronic lymphedema. The importance of a random genetic mutation occurring in hyperplastic tissue in an immunologically privileged site is discussed. Additional consideration is given, in the current case, to the possibility of viral oncogenesis and the role of ulceration as a promoter factor.
J I Epstein; G Mendelsohn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  54     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-09-06     Completed Date:  1984-09-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  943-7     Citation Subset:  AIM; IM    
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MeSH Terms
Carcinoma, Squamous Cell / complications*,  pathology,  surgery
Foot Diseases / complications*,  pathology,  surgery
Hemangiosarcoma / complications,  pathology
Lymphedema / complications*,  congenital,  pathology
Middle Aged
Skin Neoplasms / complications*,  pathology,  surgery

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