Document Detail


Squalene, olive oil, and cancer risk. Review and hypothesis.
MedLine Citation:
PMID:  10668494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiologic studies of breast and pancreatic cancer in several Mediterranean populations have demonstrated that increased dietary intake of olive oil is associated with a small decreased risk, or no increased risk, of cancer, despite a high overall lipid intake. Experimental animal models in high dietary fat and cancer also indicate that olive oil either has no effect, or a protective effect, on the prevention of a variety of chemically induced tumors. As a working hypothesis, it is proposed that the high squalene content of olive oil, as compared to other human foods, is a major factor in the cancer-risk reducing effect of olive oil. Experiments in animal models suggest a tumor-inhibiting role for squalene. A mechanism is proposed for the tumor-inhibitory activity of squalene based on its known strong inhibitory activity of HMG-COA reductase catalytic activity in vivo, thus reducing farnesyl pyrophosphate (FPP) availability for "prenylation" of ras oncogene, which relocates this oncogene to cell membranes and is required for the signal-transducing function of ras. Reduction of mutated ras oncogene activation may be useful in breast and colon cancer and may be particularly applicable to pancreatic cancers that are strongly associated with ras oncogenes.
Authors:
H L Newmark
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  889     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1999  
Date Detail:
Created Date:  2000-03-02     Completed Date:  2000-03-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-203     Citation Subset:  IM    
Affiliation:
Strang Cancer Research Laboratory, The Rockefeller University, New York, New York 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology,  therapeutic use
Breast Neoplasms* / epidemiology,  etiology,  prevention & control
Diet*
Female
Humans
Male
Pancreatic Neoplasms* / epidemiology,  etiology,  prevention & control
Plant Oils*
Risk
Squalene* / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Plant Oils; 111-02-4/Squalene; 8001-25-0/olive oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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