Document Detail

Sputum eosinophilia in Churg-Strauss syndrome.
MedLine Citation:
PMID:  11601744     Owner:  NLM     Status:  MEDLINE    
Sputum induction (IS) can be used to study airway inflammation in asthmatics and other lung diseases. However, no data are available for patients with Churg-Strauss syndrome (CSS). A study was carried out to evaluate eosinophil counts and eosinophil cationic protein (ECP) levels in induced sputum during the follow-up of three patients with CSS. Induced sputum was carried out in 10 patients with corticosteroid-dependent asthma (used as a control group). Patients with CSS had significantly higher eosinophils percentages and ECP levels in sputum than those with stable corticosteroid-dependent asthma. During the follow-up, patients with CSS presented increased ECP levels sputum and eosinophils in sputum as well as increased blood eosinophils, despite their oral corticosteroid and immunosuppressive treatment. Eosinophil percentage in sputum and the total number of eosinophils in peripheral blood were more predictive of exacerbations of CSS than sputum ECP.
H Meziane; M L Maakel; I Vachier; J Bousquet; P Chanez
Related Documents :
984584 - Occlusion pressure responses in asthma and chronic obstructive pulmonary disease.
6803634 - Familial factors affecting arterial blood gas values and respiratory chemosensitivity i...
16446314 - Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma.
3979134 - Gas exchange alterations in patients with chronic obstructive lung disease.
4079404 - Early onset of tetany following thyroidectomy: report of two cases.
25297534 - Sinus biofilms in patients with cystic fibrosis: is adjusted eradication therapy needed?
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  95     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-16     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-801     Citation Subset:  IM    
Clinique des Maladies Respiratoires and INSERM U 454, Hospital Arnaud deVilleneuve, CHU Montpellier, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Asthma / drug therapy,  immunology
Blood Proteins / analysis
Churg-Strauss Syndrome / drug therapy,  immunology*
Eosinophil Granule Proteins
Eosinophils / immunology*
Follow-Up Studies
Glucocorticoids / therapeutic use
Leukocyte Count
Middle Aged
Pilot Projects
Sputum / immunology*
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Glucocorticoids; EC 3.1.-/Ribonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Macrophages, neutrophils and tumour necrosis factor-alpha expression in bronchiectatic airways in vi...
Next Document:  Delays in the diagnosis and treatment of hospitalized patients with smear-positive pulmonary tubercu...