Document Detail


Sputum eosinophilia in Churg-Strauss syndrome.
MedLine Citation:
PMID:  11601744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sputum induction (IS) can be used to study airway inflammation in asthmatics and other lung diseases. However, no data are available for patients with Churg-Strauss syndrome (CSS). A study was carried out to evaluate eosinophil counts and eosinophil cationic protein (ECP) levels in induced sputum during the follow-up of three patients with CSS. Induced sputum was carried out in 10 patients with corticosteroid-dependent asthma (used as a control group). Patients with CSS had significantly higher eosinophils percentages and ECP levels in sputum than those with stable corticosteroid-dependent asthma. During the follow-up, patients with CSS presented increased ECP levels sputum and eosinophils in sputum as well as increased blood eosinophils, despite their oral corticosteroid and immunosuppressive treatment. Eosinophil percentage in sputum and the total number of eosinophils in peripheral blood were more predictive of exacerbations of CSS than sputum ECP.
Authors:
H Meziane; M L Maakel; I Vachier; J Bousquet; P Chanez
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  95     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-16     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-801     Citation Subset:  IM    
Affiliation:
Clinique des Maladies Respiratoires and INSERM U 454, Hospital Arnaud deVilleneuve, CHU Montpellier, France.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Asthma / drug therapy,  immunology
Blood Proteins / analysis
Churg-Strauss Syndrome / drug therapy,  immunology*
Eosinophil Granule Proteins
Eosinophils / immunology*
Female
Follow-Up Studies
Glucocorticoids / therapeutic use
Humans
Leukocyte Count
Male
Middle Aged
Pilot Projects
Ribonucleases*
Sputum / immunology*
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Glucocorticoids; EC 3.1.-/Ribonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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