Document Detail

Sputum cell counts and exhaled nitric oxide in patients with gastroesophageal reflux, and cough or asthma.
MedLine Citation:
PMID:  11521139     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gastroesophageal reflux (GER) is commonly associated with chronic cough and asthma, but there is little or no information on the nature of any associated airway inflammation. OBJECTIVE: To observe whether the association with GER worsens airway inflammation in patients with chronic cough or asthma. PATIENTS AND METHODS: The airway inflammatory indexes in induced sputum and exhaled air were examined in a cross-sectional study of 11 patients with cough and GER, nine patients with mildly symptomatic asthma and GER, nine patients with mildly symptomatic asthma without GER and nine normal, healthy control subjects. GER was shown objectively by 24 h ambulatory pH recording. RESULTS: The sputum total cell count, the proportion of neutrophils and macrophages, and the fibrinogen level were normal in all four groups, with no significant differences among the groups. The sputum eosinophil and metachromatic cell percentages, and eosinophil cationic protein levels were normal in patients with cough and GER. They were significantly increased in patients with asthma compared with healthy subjects (P<0.01) and patients with cough (P<0.01), but were not different between groups with and without GER. Exhaled nitric oxide levels showed similar results (P<0.01). The correlations between the number of episodes of reflux and the proportion of sputum eosinophils, neutrophils or exhaled nitric oxide were modest but not significant. CONCLUSIONS: GER, when associated with cough or mildly symptomatic asthma, does not cause or aggravate existing airway inflammation as measured by induced sputum cell counts and fibrinogen level, or by exhaled nitric oxide.
K Parameswaran; C J Allen; D Kamada; A Efthimiadis; M Anvari; F E Hargreave
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian respiratory journal : journal of the Canadian Thoracic Society     Volume:  8     ISSN:  1198-2241     ISO Abbreviation:  Can. Respir. J.     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-08-24     Completed Date:  2001-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9433332     Medline TA:  Can Respir J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
Asthma Research Group, Department of Medicine, , St Joseph's Healthcare and McMaster University, Hamilton, Ontario.
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MeSH Terms
Asthma / pathology*
Breath Tests
Cell Count
Cough / pathology*
Cross-Sectional Studies
Data Interpretation, Statistical
Gastroesophageal Reflux / complications*
Inflammation / pathology
Middle Aged
Nitric Oxide / analysis*
Sputum / chemistry,  cytology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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