Document Detail

'Sputnik': a programmatic approach to improve tuberculosis treatment adherence and outcome among defaulters.
MedLine Citation:
PMID:  22283898     Owner:  NLM     Status:  In-Data-Review    
SETTING: A novel patient-centered tuberculosis (TB) treatment delivery program, 'Sputnik', was introduced for patients at high risk of treatment default in Tomsk City, Russian Federation.
OBJECTIVE: To assess the effects of the Sputnik intervention on patient default rates.
DESIGN: We analyzed the characteristics of patients referred to the program, treatment adherence of Sputnik program enrollees before and during the intervention, and nal outcomes for all patients referred to the Sputnik program.
RESULTS: For patients continuing their existing regi- mens after referral to the program (n = 46), mean adherence to treatment increased by 56% (from 52% of prescribed doses prior to enrolment to 81%). For patients initiating new regimens after referral ( n = 5), mean adherence was 83%. Mean adherence for patients with multidrug-resistant TB (MDR-TB; n = 38) was 79% and for all others (n = 13) it was 89%. The cure rate was 71.1% for patients with MDR-TB, 60% for all others and 68% in the program overall.
CONCLUSION: The Sputnik intervention was successful in reducing rates of treatment default among patients at high risk for non-adherence.
I Y Gelmanova; D V Taran; S P Mishustin; A A Golubkov; A V Solovyova; S Keshavjee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  15     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-01-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  1373-9     Citation Subset:  IM    
Partners In Health, Boston, Massachusetts, USA.
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