Document Detail

Spurious underestimation of results for digoxin radioimmunoassay with a commercial kit.
MedLine Citation:
PMID:  630715     Owner:  NLM     Status:  MEDLINE    
Estimates of digoxin in serum with a commercial redioimmunoassay kit (Schwarz/Mann) occasionally result in more counts in the patient's "bound" fraction than in the "bound" fraction for the zero standard. This phenomenon has been investigated in 26 serum samples obtained from patients who were ingesting known amounts of digoxin. The problem appears to relate to environmental differences in at least the zero standard and affects results when serum digoxin concentrations are less than 0.8 microgram/liter. Apparently dose estimates are more accurate with other methods or by calculating results after omitting the zero standard.
L R Witherspoon; S E Shuler; M M Garcia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  24     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-20     Completed Date:  1978-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  494-8     Citation Subset:  IM    
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MeSH Terms
Digoxin / blood*,  therapeutic use
False Negative Reactions
Protein Binding
Reagent Kits, Diagnostic
Reg. No./Substance:
0/Reagent Kits, Diagnostic; 20830-75-5/Digoxin

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