| Spurious hypokalaemia and hypophosphataemia due to extreme hyperleukocytosis in a patient with a haematological malignancy. | |
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MedLine Citation:
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PMID: 20144973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serious hyperleukocytosis can strongly affect laboratory results of potassium, phosphate and arterial oxygen tension. A 40-year-old woman is presented with an acute myeloid leukaemia and a strongly elevated leukocyte count (310 x 10(9)/L). Apart from this hyperleukocytosis, initial blood tests showed hypokalaemia, hypophosphataemia and serious hypoxaemia without any corresponding complaints. Blood sampled and transported on ice or directly analysed showed no electrolyte abnormalities and hypoxaemia. The observed discrepancy in laboratory results is probably due to the metabolic activity of the leukocytes in vitro. Spurious laboratory results can be a reason for incorrect decisions concerning additional diagnostics and treatment. In conclusion, hyperleukocytosis can cause pseudohypokalaemia, pseudohypophosphataemia and pseudohypoxaemia, which can be prevented by correct sampling and immediate analysis. |
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Authors:
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R Polak; A Huisman; M A Sikma; S Kersting |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-02-09 |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 47 ISSN: 1758-1001 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-06-15 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: England |
Other Details:
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Languages: eng Pagination: 179-81 Citation Subset: IM |
Affiliation:
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Department of Haematology, University Medical Center Utrecht, Postbus 85.500, 3508 GA Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia / etiology* Female Hematologic Neoplasms / complications Humans Hypokalemia / complications* Hypophosphatemia / complications* Leukemia, Myeloid, Acute / complications Leukocyte Count Leukocytes / cytology*, metabolism Oxygen / blood* |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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Ann Clin Biochem. 2010 Sep;47(Pt 5):494
[PMID:
20679360
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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