| Spurious hypercalcitoninemia in patients with nodular thyroid disease induced by heterophilic antibodies. | |
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MedLine Citation:
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PMID: 19536770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum calcitonin is the most useful tumor marker for the diagnosis and follow-up of medullary thyroid carcinoma (MTC). Spurious hypercalcitoninemia caused by heterophilic antibody interference (HAI) is rarely found in patients without MTC. METHODS: We studied 2 patients with hypercalcitoninemia and thyroid nodules, but no evidence of MTC on fine-needle aspiration cytology. We performed calcium stimulation tests, measured serum calcitonin with another calcitonin kit, performed dilution tests, and remeasured serum calcitonin after applying heterophilic blocking tubes. RESULTS: In a 31-year-old woman with no response to the calcium stimulation test, serum calcitonin was <5 pg/mL using another kit. After we applied heterophilic blocking tubes, the serum calcitonin level decreased to normal range. We concluded that patient had spurious hypercalcitoninemia. In a 63-year-old woman, all tests revealed that the patient had true hypercalcitoninemia. The patient underwent total thyroidectomy that revealed MTC. CONCLUSIONS: We suggest that patients suspected for spurious hypercalcitoninemia should undergo further investigation due to HAI. |
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Authors:
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Jung Min Kim; Ki-Wook Chung; Seok Won Kim; Seon Hyeong Choi; Hye Sook Min; Ji-na Kim; Woo-jae Won; Seok Ki Kim; Ji In Lee; Jae Hoon Chung; Sun Wook Kim |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Head & neck Volume: 32 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 68-75 Citation Subset: IM |
Affiliation:
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Research Institute and Hospital, National Cancer Center, Gyeonggi, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Antibodies, Heterophile / blood, metabolism* Biopsy, Fine-Needle Calcitonin / blood* Carcinoma, Medullary / diagnosis Early Diagnosis Female Humans Middle Aged Predictive Value of Tests Prognosis Sensitivity and Specificity Thyroid Neoplasms / blood, diagnosis*, surgery Thyroid Nodule / blood, diagnosis*, surgery Thyroidectomy Thyroiditis, Autoimmune / diagnosis Treatment Outcome Tumor Markers, Biological / blood Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Heterophile; 0/Tumor Markers, Biological; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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