Document Detail

Sprouting of CGRP nerve fibers in response to dentin injury in rat molars.
MedLine Citation:
PMID:  3263169     Owner:  NLM     Status:  MEDLINE    
Light and electron microscopic immunocytochemistry showed extensive increases in the number of calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers subjacent to injured root dentin of rat molars. Sprouting was greatest at 4 days and returned to normal 10-21 days post injury. Non-CGRP-IR fibers were also increased at 4 days. The results suggest that rapid reversible sprouting of sensory nerve fibers may be an integral part of tissue reactions to injury.
P E Taylor; M R Byers; P E Redd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  461     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  371-6     Citation Subset:  IM    
Department of Endodontics, Dental School, University of Washington, Seattle 98195.
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MeSH Terms
Calcitonin Gene-Related Peptide
Dentin / injuries*,  innervation,  ultrastructure
Microscopy, Electron
Molar / injuries*
Neurons, Afferent / metabolism,  physiology*,  ultrastructure
Neuropeptides / metabolism*
Rats, Inbred Strains
Time Factors
Grant Support
Reg. No./Substance:
0/Neuropeptides; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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