| Spreading intake of a leucine-rich fast protein in energy-restricted overweight rats does not improve protein mass. | |
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MedLine Citation:
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PMID: 22189192 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Energy restriction decreases fat mass and fat-free mass. Our aim was to prevent the latter using type and timing of protein nutrition as tools. METHODS: Young male Wistar rats were given a high-energy diet for 5 wk and then energy restricted and fed a high-protein diet containing caseins, milk-soluble proteins (MSP), or a casein-MSP mixture (n = 9 per group) as the only source of protein for 3 wk. Food intake was spread over 12 h, whereas in a previous experiment rats consumed their daily ration within 2 to 3 h. Weight and food intake were recorded. The body composition was measured by dual-energy x-ray absorptiometry before and after energy restriction. After 3 wk, the hind-limb muscles, the kidney, intestine, liver, and spleen weights, metabolic plasma parameters, and the liver and extensor digitorum longus muscle protein synthesis rates were measured in the postprandial state. RESULTS: The food intake was similar in all groups. Energy restriction induced a significant decrease in body weight and fat mass (P < 0.001) and stopped the slow growth of lean body mass, with no differences between groups. Among all tissues, a significant effect was detected only for the intestine (P = 0.0012), with a higher weight in the casein group. Postprandial liver and muscle protein synthesis rates were not different between groups. CONCLUSION: When using a high-protein diet spread over 12 h, the nature of the protein intake has no influence on the sparing of lean body mass during energy restriction in young overweight rats. |
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Authors:
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Solange Adechian; Didier Rémond; Claire Gaudichon; Corinne Pouyet; Dominique Dardevet; Laurent Mosoni |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: - ISSN: 1873-1244 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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INRA, UMR 1019 Nutrition Humaine, Saint Genès Champanelle, France; Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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