Document Detail


Spreading Ischemia After Aneurysmal Subarachnoid Hemorrhage.
MedLine Citation:
PMID:  22890658     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Spreading depolarization (SD) is a wave of mass neuronal and glial depolarization associated with net influx of cations and water. Prolonged SDs facilitate neuronal death. SD induces tone alterations in cerebral resistance arterioles, leading to either transient hyperperfusion (physiological neurovascular coupling) in healthy tissue or hypoperfusion (inverse neurovascular coupling = spreading ischemia) in tissue at risk for progressive damage. Spreading ischemia has been shown experimentally in an animal model replicating the conditions present following aneurysmal subarachnoid hemorrhage (aSAH), in animal models of the ischemic core and penumbra following middle cerebral artery occlusion, and in patients with aSAH. In animals, spreading ischemia produced widespread cortical necrosis. In patients, spreading ischemia occurred in temporal correlation with ischemic lesion development early and late after aSAH. We briefly review important features of SD and spreading ischemia following aSAH.
Authors:
Jens P Dreier; Christoph Drenckhahn; Johannes Woitzik; Sebastian Major; Nikolas Offenhauser; Steffen Weber-Carstens; Stefan Wolf; Anthony J Strong; Peter Vajkoczy; Jed A Hartings;
Related Documents :
2158008 - Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat cen...
11490308 - Histological and neurotrophic changes triggered by varying models of bladder inflammation.
8867048 - Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not ne...
20518608 - Use of growth factors for the treatment of parkinson's disease.
14625778 - Neuronal apoptosis following human brain injury.
9469258 - Effects of aging and dementia on the levels of thiobarbituric-acid-reactive products st...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  115     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2013  
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  125-129     Citation Subset:  -    
Affiliation:
Center for Stroke Research Berlin, Campus Charité Mitte, Charité University Medicine Berlin, Charitéplatz 1, Berlin, 10117, Germany, jens.dreier@charite.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Computerized occlusion rating of embolized ruptured intracranial aneurysms: relation to intra- and p...
Next Document:  Full-band electrocorticography of spreading depolarizations in patients with aneurysmal subarachnoid...