Document Detail


Spread of methicillin-resistant Staphylococcus aureus in a hospital after exposure to a health care worker with chronic sinusitis.
MedLine Citation:
PMID:  8218696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A dramatic increase in the incidence of methicillin-resistant Staphylococcus aureus at a teaching hospital was documented to be due to three factors: a hospital-wide outbreak of 32 cases caused by an epidemic strain, an increase in the number of nosocomial cases caused by several other strains, and an increase in the number of patients admitted carrying strains acquired at other institutions. Case patients with the epidemic strain were significantly more likely than control patients to have had previous exposure to a respiratory therapist (P = .005) who had chronic sinusitis due to the epidemic strain. The plasmid DNA of isolates from the implicated respiratory therapist and affected patients yielded the same patterns on restriction endonuclease digestion. Implementation of general control measures and eradication of the respiratory therapist's sinusitis and nasal carriage terminated the epidemic. Establishing the importance of the infected health care worker by epidemiological methods led to control of the outbreak without the institution of wide-scale culture of specimens from personnel and the environment or other expensive and labor-intensive measures.
Authors:
J M Boyce; S M Opal; G Potter-Bynoe; A A Medeiros
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  17     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-15     Completed Date:  1993-12-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  496-504     Citation Subset:  IM    
Affiliation:
Division of Infectious Diseases, Miriam Hospital, Providence, Rhode Island 02906.
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Chronic Disease
Cross Infection / epidemiology,  prevention & control,  transmission*
Disease Outbreaks*
Female
Humans
Infectious Disease Transmission, Professional-to-Patient*
Male
Methicillin Resistance
Middle Aged
Plasmids
Respiratory Therapy*
Sinusitis / microbiology*
Staphylococcal Infections / epidemiology,  prevention & control,  transmission*
Staphylococcus aureus / drug effects,  genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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