| The Spread of Excitation in the Embryonic Chick Heart. | |
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MedLine Citation:
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PMID: 19873568 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The spread of excitation in embryonic chick hearts, ranging in age from 7 to 20 days, was studied with both intracellular and extracellular electrodes. Evidence that the delay in ventricular excitation could be attributed to the cells of the entire atrioventricular (AV) ring was obtained, in part, from sagittal sections of the heart. In the intact preparation, uniform propagation occurred throughout the atrial roof at an apparent conduction velocity of 0.4 to 0.5 meter/sec. Delay of impulse propagation was localized in a very narrow band of tissue which extended across the AV ring. The apparent conduction velocity of this tissue was between 0.003 and 0.005 meter/sec. Both normal and retrograde propagation revealed the spread of conduction across the AV ring to be decremental in nature. This finding was supported by high frequency stimulation experiments which gave rise to AV block localized in the cells of the AV ring. Cardiac rhythmicity and AV transmission were responsive to acetylcholine and norepinephrine in much the same manner as in the adult mammalian heart. The present findings are in support of the hypothesis that the embryonic AV ring is the functional counterpart of the adult AV node. |
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Authors:
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M Lieberman; A Paes de Carvalho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of general physiology Volume: 49 ISSN: 0022-1295 ISO Abbreviation: J. Gen. Physiol. Publication Date: 1965 Nov |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-06-22 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 2985110R Medline TA: J Gen Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 365-79 Citation Subset: - |
Affiliation:
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Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York, and Instituto de Biofisica, Universidade do Brasil, Rio de Janeiro, Brasil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Gen Physiol ISSN: 0022-1295 ISSN: 1540-7748 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1966 by The Rockefeller University Press Received Day: 8 Month: 3 Year: 1965 Print publication date: Day: 1 Month: 11 Year: 1965 Volume: 49 Issue: 2 First Page: 365 Last Page: 379 ID: 2195477 PubMed Id: 19873568 |
| The Spread of Excitation in the Embryonic Chick Heart | |
| Melvyn Lieberman | |
| Antonio Paes de Carvalho | |
| From the Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York, and Instituto de Biofisica, Universidade do Brasil, Rio de Janeiro, Brasil. |
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| Dr. Lieberman's present address is the Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland. Dr. Paes de Carvalho's present address is Instituto de Biofisica, Universidade do Brasil, Rio de Janeiro, Brasil |
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