Document Detail


Spore germination in Mortierella alpina is associated with a transient depletion of arachidonic acid and induction of fatty acid desaturase gene expression.
MedLine Citation:
PMID:  17492269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mortierella alpina is an oleaginous filamentous fungus whose vegetative mycelium is known to accumulate triglyceride oil containing large amounts of arachidonic acid (ARA 20:4, n - 6). We report that the spores of Mortierella alpina also contain a large proportion of ARA, comprising 50% of total fatty acid. Fatty acid desaturase genes were not expressed in dormant spores but were induced during germination, following a significant drop in the level of ARA (down from 50% of total fatty acid to 12%) prior to germ-tube emergence. We propose that ARA serves as a reserve supply of carbon and energy that is utilised during the early stages of spore germination in Mortierella alpina.
Authors:
C Lounds; J Eagles; A T Carter; D A MacKenzie; D B Archer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-10
Journal Detail:
Title:  Archives of microbiology     Volume:  188     ISSN:  0302-8933     ISO Abbreviation:  Arch. Microbiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0410427     Medline TA:  Arch Microbiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Affiliation:
School of Biology, University of Nottingham, University Park, Nottingham, UK.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AM411536;  AM411537;  AM411538;  AM411539
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acid / metabolism*
Base Sequence
DNA, Fungal / chemistry,  genetics
Fatty Acid Desaturases / biosynthesis*,  genetics
Gene Expression Regulation, Fungal*
Molecular Sequence Data
Mortierella / growth & development*,  metabolism*
RNA, Fungal / biosynthesis
RNA, Messenger / biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Spores, Fungal / chemistry*,  genetics
Chemical
Reg. No./Substance:
0/DNA, Fungal; 0/RNA, Fungal; 0/RNA, Messenger; 506-32-1/Arachidonic Acid; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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