| Sporamin induce apoptosis in human tongue carcinoma cells by down-regulating Akt/GSK-3 signaling. | |
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MedLine Citation:
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PMID: 20408878 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We investigated the effects of sporamin, the major soluble protein with a kunitz-type trypsin inhibitory activity in the root tuber of the sweet potato, on cell proliferation, apoptosis, Akt/GSK-3 signaling and its related genes to provide more insights in the mechanism behind the inhibitory effects of sporamin in a human tongue cancer line Tca8113. In this study, sporamin inhibited cell proliferation and induced apoptosis in Tca8113 cells in a concentration-dependent and time-dependent manner. Consistently, Bax was up-regulated and Bcl-2 was down-regulated in sporamin-treated cells. Furthermore, Akt/GSK-3 signaling was down-regulated in sporamin-treated cells. Consistently, the phosphorylated Bad was significantly declined in sporamin-treated Tca8113 cells. These results suggest the antiproliferative effects of sporamin in Tca8113 cells might result partly from induction of apoptosis by down-regulating Akt/GSK-3 pathway. |
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Authors:
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Jun Yao; Cuijuan Qian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 25 ISSN: 1472-8206 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 229-36 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors Fundamental and Clinical Pharmacology © 2010 Société Française de Pharmacologie et de Thérapeutique. |
Affiliation:
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School of Medicine, Taizhou University, Jiaojiang District, Taizhou, Zhejiang 318000, China Department of Gastroenterology, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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