| Sporadic and hereditary primary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 21985979 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Primary hyperparathyroidism (PHPT) is a common endocrine disorder, particularly frequent in post-menopausal women. It is characterized by hypercalcemia with inappropriately high spontaneous plasma PTH. Singlegland adenoma is the most common cause (75- 85%). PHPT is usually a sporadic disease but in approximately <5% of cases, a familial hyperparathyroid syndrome is diagnosed. Familial hyperparathyroidism is a clinically and genetically heterogeneous group of disorders including: multiple endocrine neoplasia (MEN) type 1, MEN type 2A, MEN4, benign familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, hyperparathyroidism-jaw tumor syndrome, and familial isolated hyperparathyroidism. These syndromes show mendelian inheritance patterns and the main genes for most of them have been defined. The classic form of PHPT, which presents with hypercalcemia, kidney stones, and bone disease, is no longer common. Currently, there is an increasing interest in the subtle manifestations of PHPT, particularly the cardiovascular and neuropsychiatric manifestations. Parathyroidectomy is the definitive cure for PHPT even though patients with the asymptomatic form of the disease can be followed conservatively. |
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Authors:
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J Pepe; C Cipriani; R Pilotto; F De Lucia; C Castro; L Lenge; S Russo; V Guarnieri; A Scillitani; V Carnevale; E D'Erasmo; E Romagnoli; S Minisola |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 34 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 40-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Medical Disciplines, University of Rome "Sapienza", Viale del Policlinico 155, 00161 Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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