Document Detail


Sporadic and epidemic community legionellosis: two faces of the same illness.
MedLine Citation:
PMID:  17005576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study compares the risk factors, presentation and outcome of community-acquired Legionella pneumophila pneumonia in 138 sporadic-case patients (1994-2004) and 113 outbreak-case patients (2002) treated in two hospitals in Catalonia (Spain) since urinary antigen assays were adopted. Univariate and multivariate analysis were performed to compare epidemiological and clinical features, blood chemistry values, radiological findings and outcome of sporadic and epidemic legionnaires' disease. Univariate analysis showed that male sex, chronic lung disease, HIV infection and immunosuppressive therapy prevailed in sporadic cases. Presentation with respiratory symptoms, confusion and blood chemistry alterations, such as hyponatraemia, aspartate aminotransferase and blood urea nitrogen elevation, and partial pressure of oxygen P(O)(2) <7.98 KPa (60 mmHg) were also more frequent in sporadic cases, while headache prevailed in outbreak cases. Sporadic cases had a greater delay in treatment, were more severe and had a worse outcome than epidemic cases. Multivariate analysis showed significant differences in sex, chronic lung disease, HIV infection and headache. The clinical and outcome differences between the two groups may be explained by the detection of milder forms of legionnaires' disease, the earlier treatment and the lower severity of underlying disease in the outbreak cases.
Authors:
N Sopena; L Force; M L Pedro-Botet; P Barrufet; G Sauca; M García-Núñez; G Tolchinsky; J A Capdevila; M Sabrià
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-09-27
Journal Detail:
Title:  The European respiratory journal     Volume:  29     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-03-20     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  138-42     Citation Subset:  IM    
Affiliation:
Infectious Diseases Unit, Germans Trias i Pujol University Hospital, Badalona, Spain. nsopena.germanstrias@gencat.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Bacterial Agents / therapeutic use
Community-Acquired Infections / diagnosis,  epidemiology,  therapy
Disease Outbreaks*
Female
Hospitalization
Humans
Legionnaires' Disease / diagnosis*,  epidemiology*,  therapy
Male
Middle Aged
Retrospective Studies
Risk Factors
Spain
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents
Comments/Corrections
Comment In:
Eur Respir J. 2007 Oct;30(4):813   [PMID:  17906095 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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