| Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. | |
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MedLine Citation:
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PMID: 18599790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sudden infant death syndrome is the leading cause of death in the postneonatal period in developed countries. Postmortem studies show alterations in serotonin neurons in the brainstem of such infants. However, the mechanism by which altered serotonin homeostasis might cause sudden death is unknown. We investigated the consequences of altering the autoinhibitory capacity of serotonin neurons with the reversible overexpression of serotonin 1A autoreceptors in transgenic mice. Overexpressing mice exhibited sporadic bradycardia and hypothermia that occurred during a limited developmental period and frequently progressed to death. Moreover, overexpressing mice failed to activate autonomic target organs in response to environmental challenges. These findings show that excessive serotonin autoinhibition is a risk factor for catastrophic autonomic dysregulation and provide a mechanism for a role of altered serotonin homeostasis in sudden infant death syndrome. |
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Authors:
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Enrica Audero; Elisabetta Coppi; Boris Mlinar; Tiziana Rossetti; Antonio Caprioli; Mumna Al Banchaabouchi; Renato Corradetti; Cornelius Gross |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 321 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-07-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 130-3 Citation Subset: IM |
Affiliation:
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Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Via Ramarini 32, 00015 Monterotondo, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System / physiology* Autoreceptors / metabolism Body Temperature Doxycycline / pharmacology Electrocardiography Feedback, Physiological Heart Rate Homeostasis Humans Infant Mice Mice, Transgenic Motor Activity Neural Inhibition* Neurons / metabolism, physiology* Piperazines / administration & dosage, pharmacology Pyridines / administration & dosage, pharmacology Raphe Nuclei / cytology, metabolism Receptor, Serotonin, 5-HT1A / genetics, metabolism Serotonin / metabolism* Serotonin Antagonists / administration & dosage, pharmacology Sudden Infant Death / etiology* Sympathetic Nervous System / physiology Synaptic Transmission Tryptophan / metabolism, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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MH64948/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoreceptors; 0/Piperazines; 0/Pyridines; 0/Serotonin Antagonists; 112692-38-3/Receptor, Serotonin, 5-HT1A; 146714-97-8/WAY 100635; 50-67-9/Serotonin; 564-25-0/Doxycycline; 73-22-3/Tryptophan |
| Comments/Corrections | |
Comment In:
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Science. 2008 Nov 7;322(5903):856-7; author reply 856-7
[PMID:
18988825
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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