| Sporadic Larsen syndrome in a preterm female originally diagnosed as positional deformities due to oligohydramnios. | |
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MedLine Citation:
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PMID: 16450278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few reports describe incidental prenatal diagnosis of sporadic Larsen syndrome by ultrasound, but none of these discuss coincidental oligohydramnios or an association with fetal growth restriction. A 28-year-old woman had prolonged rupture of membranes causing marked oligohydramnios at 32 weeks gestation in her first pregnancy. Labor was induced by vaginal prostaglandins and oxytocin infusion after dexamethasone administration because of concern about placental abruption. She delivered vaginally a live female infant weighing 1960 g (< 10th percentile) with multiple skeletal malformations and characteristic facies originally suspected as positional. Newborn x-rays, however, established the diagnosis of Larsen syndrome with bilateral dislocations of the hips, knees (genu recurvatum), and ankles (club foot). The neonatal karyotype was 46,XX. Parental examination and family history were unremarkable. The newborn did well with bilateral lower extremities cast. Postnatal diagnosis of Larsen syndrome should be suspected in neonates with multiple skeletal abnormalities following oligohydramnios. |
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Authors:
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Diaa E E Rizk; Krishnan R Nath; Intisar K Ibrahim; Nizar A Arafat; Lihadh I Al-Gazali |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 23 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-01 Completed Date: 2006-05-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 71-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Facies Female Fetal Growth Retardation / physiopathology Humans Infant, Newborn Lower Extremity Deformities, Congenital / diagnosis*, etiology, therapy Oligohydramnios / physiopathology Pregnancy Premature Birth Syndrome |
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