Document Detail


Sporadic Creutzfeldt-Jakob disease--a review.
MedLine Citation:
PMID:  19863257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective is to study a patient with sporadic Creutzfeldt-Jakob disease (CJD). The patient, a 70-year-old woman with a history spanning over 1 month, with acute onset, progressive abnormal behavior, and cognitive decline with generalized asymmetrical myoclonic jerking, startle phenomenon, and cortical blindness, was referred to the hospital. On observation of clinical symptoms, metabolic and hematological investigations, MRI (magnetic resonance imaging), and EEG (electroencephalogram) were done. The clinical symptoms, MRI, and diagnostic EEG were suggestive of sporadic CJD. Other metabolic encephalopathies were ruled out. With sodium valproate and clonezepam, her myoclonic jerks improved slightly. As CJD is an incurable disease, no definitive treatment could be given.
Authors:
Stuti Sharma; Madhurima Mukherjee; Vivekananda Kedage; Manjunatha S Muttigi; Anjali Rao; Suryanarayana Rao
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  119     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-29     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1981-94     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
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MeSH Terms
Descriptor/Qualifier:
Aged
Animals
Brain / metabolism,  pathology,  physiopathology
Creutzfeldt-Jakob Syndrome / genetics,  metabolism,  physiopathology*
Dementia / genetics,  metabolism,  physiopathology
Diagnosis, Differential
Disease Progression
Female
Humans
Myoclonus / drug therapy,  etiology,  physiopathology
Prion Diseases / genetics,  metabolism,  physiopathology*
Prions / chemistry,  genetics,  metabolism*
Protein Structure, Secondary / physiology
Chemical
Reg. No./Substance:
0/Prions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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